Summary

This open-label Phase 1 study will evaluate the safety, PK, and antitumor activity of
modified T cells (JCAR017) administered to adult patients with relapsed or refractory B-cell
NHL. The dose and schedule of JCAR017 will be evaluated and modified, as needed, for safety
and antitumor activity. We will also determine how long the modified T cells stay in the
patient's body and how well JCAR017 works in treating patients with non-Hodgkin's lymphoma
whose disease has come back or has not responded to treatment.

Objectives

This is an open-label, multicenter Phase 1 study to determine the safety, pharmacokinetics
(PK), and antitumor activity of JCAR017 in adult patients with relapsed or refractory diffuse
large B cell lymphoma (DLBCL), primary mediastinal B-cell lymphoma (PMBCL), follicular
lymphoma Grade 3B, and mantle cell lymphoma (MCL). This study will evaluate and refine the
dose and schedule of JCAR017 to optimize safety and antitumor activity. A dose-confirmation
group or groups will further evaluate the safety and efficacy of JCAR017 at the recommended
regimen(s).

Upon successful generation of JCAR017 product, participants will receive treatment with one
or more cycles of JCAR017 therapy. Each cycle will include lymphodepleting chemotherapy
followed by one or two doses of JCAR017 administered by intravenous (IV) injection.

The follow-up period for each participant is approximately 24 months after the final JCAR017
infusion. Long-term follow-up for survival, toxicity, and viral vector safety will continue
under a separate long-term follow-up protocol per health regulatory authority guidelines,
currently up to 15 years after the last JCAR017 infusion.