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TAPUR: Testing the Use of Food and Drug Administration (FDA) Approved Drugs That Target a Specific Abnormality in a Tumor Gene in People With Advanced Stage Cancer

Status
Active
Cancer Type
Multiple Myeloma
Non-Hodgkin Lymphoma
Plasma cell neoplasm
Trial Phase
Phase II
Eligibility
12 Years and older, Male and Female
Study Type
Treatment
NCD ID
NCT02693535
Protocol IDs
Pro00014171 (primary)
NCI-2017-00510
Study Sponsor
American Society of Clinical Oncology
NCI Full Details
http://clinicaltrials.gov/show/NCT02693535

Summary

The purpose of the study is to learn from the real world practice of prescribing targeted
therapies to patients with advanced cancer whose tumor harbors a genomic variant known to be
a drug target or to predict sensitivity to a drug.

NOTE: Due to character limits, the arms section does NOT include all TAPUR Study relevant
biomarkers. For additional information, contact TAPUR@asco.org, or if a patient, your nearest
participating TAPUR site (see participating centers).

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Results in publication or poster presentation format are posted as they become available for
individual cohorts at www.tapur.org/news. The results may be accessed at any time. All
results will be made available on clinicaltrials.gov at the end of the study. Indexing of
available results on PubMed is in progress.

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Objectives

The Targeted Agent and Profiling Utilization Registry (TAPUR) Study is a non-randomized
clinical trial that aims to describe the safety and efficacy of commercially available,
targeted anticancer drugs prescribed for treatment of patients with advanced cancer that has
a potentially actionable genomic variant. TAPUR will study Food and Drug Administration
(FDA)-approved targeted therapies that are contributed by collaborating pharmaceutical
companies, catalogue the choice of molecular profiling test by clinical oncologists and
develop hypotheses for additional clinical trials.
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